SAXS FA 1 - MS 05 - P 11 Structural Analysis of 1 - aryl - 3 - isopropilamino - 1 -

Mannich bases are generally formed by the reaction between formaldehyde, a secondary amine and a compound containing reactive hydrogen atoms. They display varied biological activities such as antimicrobial [1], cytotoxic [2,3], anticancer [2], analgesic [4], anti-inflammatory [5] and anticonvulsant [6] and DNA topoisomerase I inhibiting activities [3]. In this study, it was planned to synthesize some Mannich bases having the chemical structure of 1-aryl-3isopropilamino-1-propanone hydrochlorides, which are possible cytotoxic/ anticancer compounds. Aryl part was changed as C6H5, 4-CH3C6H4, 4-ClC6H4, 4-BrC6H4, 4HOC6H4. The logic behind the synthesis of the compounds was to investigate the effect of substituents having different electronic nature. The chemical structures of the compounds were determined by X-Ray diffraction, H-NMR, C-NMR, DEPT, gCOSY, gHMQC, GHMBC and double resonance techniques.